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Zinc induced polyelectrolyte coacervate bioadhesive and its transition to a self-healing hydrogel
Citation key wang15
Author Wang, W. and Xu, Y. and Li, A. and Li, T. and Liu, R. and von Klitzing, R. and Ober, C. K. and Kayitmazer, L. and Lia, L. and Guo, X.
Pages 66871 - 66878
Year 2015
DOI 10.1039/C5RA11915D
Journal RSC Advances
Volume 5
Abstract To mimic the underwater adhesion of marine mussels, a bioadhesive has been prepared with a poly(acrylic acid) backbone functionalized with 30% catechol appendants. The polyelectrolyte chains can be reversibly crosslinked through metal chelation and irreversibly gelled by oxidative crosslinking. Surprisingly, the reported “poor” metal chelator Zn2+ not only imparts this injectable adhesive with superior adhesion after the formation of coacervation compared to the one chelated by a stronger metal crosslinker (e.g. Fe3+), but also generates good mechanical performance of the self-healing hydrogel after the oxidation of catechol groups with a pH trigger. Such a pH-responsive material with strong adhesion and good self-healing property at different conditions could be an ideal candidate in biomedical adhesion and tissue engineering.
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